Table 2

Timing of apoptotic events in the ovulated Xenopus eggs and in vitro-matured oocytes.

Events in eggs

Control eggs

PG-treated oocytes

Ionophore-

activated eggs

Roscovitine-

treated eggs


Meiotic exit

within 18 h

within 24 h

within 45 min

within 6 h

Cytochrome c release

24 h

24-36 h

18 h

ND*

Caspase 3/7 activation

24-36 h

48-60 h

18-24 h

18-36 h

ATP decrease

30 h

60 h

24 h

24 h

ADP/ATP increase

30 h

60 h

24 h

24 h

Drop in intracellular pH (< 6.0)

36 h

60 h

36 h

ND*

Increase in egg diameter

36 h

60 h

36 h

24 h


*not determined

Tokmakov et al. BMC Cell Biology 2011 12:56   doi:10.1186/1471-2121-12-56

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