Alignment of the C-terminal sequences of MEK1 and MEK2. The last three residues of MEK2 proteins (with the exception of MEK2 from chicken) suggest that MEK2 is characterized by a Class I PDZ-binding motif. This motif is absent in MEK1 proteins. A set of three conserved basic residues (highlighted in black) is also a feature specific of MEK2 proteins. The sources for the aligned sequences are: human MEK2 (hMEK2, NP_109587), mouse MEK2 (mMEK2, AAH14830), rat MEK2 (rMEK2, 2113192A), chicken MEK2 (chMEK2, NP_990719), human MEK1 (hMEK1, NP_002746), mouse MEK1 (mMEK1, NP_032953), rat MEK1 (rMEK1, NP_113831), and rabbit MEK1 (rbMEK1, P29678).
Gaudet et al. BMC Cell Biology 2011 12:55 doi:10.1186/1471-2121-12-55