Open Access Research article

A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung

Zhang Li13, Rayman Choo-Wing14, Huanxing Sun1, Angara Sureshbabu1, Reiko Sakurai2, Virender K Rehan2 and Vineet Bhandari1*

Author Affiliations

1 Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA

2 Division of Neonatology, Department of Pediatrics, Harbor UCLA Medical Center, David Geffen School of Medicine at UCLA, Torrance, CA, 90502, USA

3 Department of Anesthesiology, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Lixia District, 250012 Jinan, Shandong, China

4 Department of Systems Biology, Beth Israel Deaconess Medical Center, Center for Life Sciences, 3 Blackfan Circle, Boston, MA 02115, USA

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BMC Cell Biology 2011, 12:54  doi:10.1186/1471-2121-12-54

Published: 15 December 2011

Additional files

Additional file 1:

Figures S1-3 and Table S1. The additional file figures S1-3 show the effect of JNK inhibition on total JNK and phosphorylated-JNK (P-JNK), cell death and cell death mediators in hyperoxia-exposed cells. The additional file Table S1 shows the numerical values of cell death in hyperoxia-exposed cells.

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