Chronotropical responses of bioreactor-derived cardiomyocytes. A) Variation in the number of beatings after drug application. The highest change was due to application of Bay K8664. B) Changes in beating rate. The frequency of changes in beating clearly showed the development of mature ion channels in the membrane of cardiomyocytes, which enabled them to respond to drugs (P < 0.05).
Shafa et al. BMC Cell Biology 2011 12:53 doi:10.1186/1471-2121-12-53