Model depicting the role of SOX4 and plakoglobin in Wnt signaling regulation. When cells are stimulated with WNT3A, Wnt-responsive genes are upregulated by nuclear localization of β-catenin and transcriptional activation by the β-catenin-TCF/LEF and β-catenin-SOX4 complexes. Plakoglobin then shuttles into the nucleus and is exported out of the nucleus with SOX4. When nuclear export is inhibited by LMB, plakoglobin competes with β-catenin for SOX4 binding, destabilizes SOX4 binding to target promoters, and inhibits transcription of target genes.
Lai et al. BMC Cell Biology 2011 12:50 doi:10.1186/1471-2121-12-50