Table 1

Interactors of the C1-C2 region of cMyBPC in the trisphospho-mimic state as identified by yeast 2-hybrid library screening

Clone #

Genomic Hit, Accession no (E-value)

In-frame ORF Protein Hit, Accession no (E-value)

Subcellular localization


P205, P272, P403

PDE4DIP, transcript 4 NM_001002810 (0.0)

Homo sapiens phosphodiesterase 4D interacting protein (myomegalin)

    NP_055459.3
(1e-70)

Cytoplasm, Cytoskeleton

P182, P286, P267

ACTC1 NM_005159 (0.0)

Homo sapiens actin, alpha, cardiac muscle 1 NP_005150 (1e-89)

Thin filament sarcomere

P259

ACTCB NM_001101 (0.0)

Homo sapiens actin, beta

    AAH23548.1 (8e-34)

Cytoplasm, cytoskeleton

P62, P213, P319

MYBPC3 NM_000256 (0.0)

Homo sapiens cardiac myosin binding protein C,

    NP_000247.2
(2e-26)

Thick filament; Sarcomere

P2,P81

Gcom1 transcript 12 NM_001018100 (0.0)

Homo sapiens GRINL1A combined protein NP_001018100.1, (2e-65)

Unknown

P80

FLNC

    NM_001458.2 (0.0)

Homo sapiens filamin C, gamma

    NP_001449.3 (2e-91)

Myofibrillar z-disks; actin cytoskeleton

P175, P465

CNN1 NM_001299.4 (0.0)

Homo sapiens calponin 1, basic, smooth muscle NP_001290.2 (1e-104)

Cytoplasm, cytoskeleton

P11

PARD3

    NM_019619.2 (3e-121)

Homo sapiens par-3 partitioning defective 3 homolog

    NP_062565.2 (1e-24)

Plasma membrane; tight junctions

P223

CCT7 NM_001009570.1 (0.0)

Homo sapiens chaperonin containing TCP1, subunit 7 (eta)

    NP_001009570.1 (1e-83)

Cytoplasm

P238

SVIL

    NM_021738.1 (0.0)

Homo sapiens supervillin

    NP_003165.1 (1e-15)

Actin cytoskeleton, plasma membrane, nucleus

P398

FLJ21347

    NM_022827.2 (0.0)

FLJ21347

    NP_073738.2 (4e-101)

Unknown


Uys et al. BMC Cell Biology 2011 12:18   doi:10.1186/1471-2121-12-18

Open Data