High apoptosis rate but low STAT5A expression in U-HO1-PTPN1. A. Apoptotic cells (M2), on the left to the G1 peak on the x-axis, are about 4 times more frequent in U-HO1-PTPN1. B. Abundant phosphorylated STAT5A is present in the cytoplasm of U-HO1 mononuclear H- and multinuclear RS-cells (left panel) but is barely present in U-HO1-PTPN1 (right panel). Note numerous bi- or multinucleated RS-cells in U-HO1-PTPN1 but not in U-HO1.
Knecht et al. BMC Cell Biology 2010 11:99 doi:10.1186/1471-2121-11-99