Additional file 1.
MLP29 cells were treated with a specific functional blocking antibody against α5β1 integrin or stimulated with HGF/SF1 for 24 hours. Then immunofluorescent detection of invasiveness and hepatic stem cell (HSC) biomarkers showed that cell migration was associated with an increase in the expression levels of β1 and β3 integrin sub-units. The treatments also increased the expression of the HSC markers Ep-CAM, AFP and CK19, all related to the invasive growth of epithelial cells.
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Vellón et al. BMC Cell Biology 2010 11:81 doi:10.1186/1471-2121-11-81