Figure 6.

A schematic representation of PGF-FP receptor signalling which differentially regulates endothelial network formation and proliferation. PGF-FP receptor signalling in epithelial cells promotes the release of FGF2 into culture medium (conditioned medium). Conditioned medium treatment of HUVECs promotes the activation of ERK1/2 signalling via the FGF2-FGFR1. ERK1/2 activates divergent signalling pathways to endothelial proliferation and network formation. Endothelial proliferation is activated via mTOR. Endothelial network formation is activated via the induction of endothelial COX-2 enhancing the biosynthesis and release of PGF. Endothelial PGFsubsequently acts on endothelial FP receptors to promote network formation (endothelial differentiation).

Keightley et al. BMC Cell Biology 2010 11:8   doi:10.1186/1471-2121-11-8
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