Proliferation enhancement effects of GDNF on cultured ISCs is completely abolished by the ERK1/2 inhibitor PD98059. (A-D) BrdU-positive cells in control (A), PD98059 treated (B), GDNF stimulated (C) and pre-treated with PD98059 plus GDNF stimulation groups (D). (E) Quantitative analysis results. The data were presented as means ± SD from three independent experiments. Statistically significant differences (p < 0.05) among groups are indicated by an asterisk. Scale bar indicates 10 μm.
Yang and Han BMC Cell Biology 2010 11:78 doi:10.1186/1471-2121-11-78