Myc and protein starvation regulate similar genes, particularly those involved in ribosome synthesis and mRNA translation. A. Heat map of ribosome biogenesis and mRNA translation genes. Each column represents change in gene expression following starvation, Myc overexpression or PI3K overexpression. Columns indicate expression changes at different time-points B, Venn diagram showing overlap in genes whose expression is either decreased (left panel) or increased (right panel) in both Myc null mutants and protein starved mutants. C. Heat map of genes affected by Myc overexpression, starvation or Myc overexpression in starved larvae. D. Venn diagram showing the overlap in genes up-regulated in starved animals by either re-feeding or by Myc overexpression.
Li et al. BMC Cell Biology 2010 11:7 doi:10.1186/1471-2121-11-7