Table 1

Selected list of induced genes comparing uninduced cells to cells expressing insulin 2 (C96Y)-EGFP for 24 h, 48 h and 5 days identified by Affymetrix rat genome arrays.

Gene Name

Entrez Gene ID

Putative Function

Fold Change


24 h

48 h

5d


Protein modification/folding

Sdf2l1

680945

O-mannosylation?

5.7

4.7

10.9

Fkbp11

300211

Peptidyl-prolyl isomerase

2.9

3.9

4.3

Dnajb9/Erdj4

24908

Protein folding

2.5

3

3.1

Dnajc3/P58IPK

63880

Protein folding

2.3

2.8

4.2

Dnajb11/Erdj3

360734

Protein folding

2.2

2.4

3

Pdia2

287164

PDI family, isomerase

3.1

2.7

Pdia3/Erp57

29468

PDI family, isomerase

3.2

3.2

Pdia4/Erp72

116598

PDI family, isomerase

3.1

3.1

Hspa5/Grp78

25617

ER Protein folding

2.6

Pdia6/P5

286906

PDI family, isomerase

3

Txndc4/Erp44

298066

PDI family, isomerase

2

ER stress-inducible

Herp

85430

ERAD

3.3

4.3

3.5

Sel1h

314352

ERAD

2.5

2.7

2.6

Atf4

79255

Transcription factor

2.7

3

Chop/Gadd153

29467

Transcription factor

2.5

3.5

2.7

Trib3/Trb3

246273

11.5

19.8

6.7

Transcription factors

Mist1

25334

Transcription factor

2.9

3.2

3.7

Atf5

282840

Transcription factor

2.4

3.3

Protein transport

Kdelr3

315131

Vesicle transport

2.1

2.9

3.8

Tmed3

300888

Vesicle transport

2.4

2.8

Selected others

Creld2

362978

ER Protein folding?

3.6

3.6

7

Armet

315989

2.8

2.8

3.9

Myo1g

289785

Motor protein

2.3

2.9

2.5

Ell3

296102

RNA polymerase II-like 3

2.1

2.2

3.6

Magt1

116967

Magnesium transporter

2.1

2.3

2.4

Oat

64313

Ornithine aminotransferase

2

2.3

2.8


Mean fold change from three independent experiments for each time point is shown. Bold indicates the gene was induced in at least 2 independent experiments and italics indicates average induction value of multiple probes for the same gene.

Hartley et al. BMC Cell Biology 2010 11:59   doi:10.1186/1471-2121-11-59

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