Research article
Hydrogen peroxide stimulates nuclear import of the POU homeodomain protein Oct-1 and its repressive effect on the expression of Cdx-2
1 Div. of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 10-354 Toronto Medical Discovery Tower, The MaRS Building, 101 College St., Toronto, Ontario, M5G 1L7, Canada
2 Dept. of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5 S 1A8, Canada
3 Dept. of Medicine, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada
4 Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5 S 1A8, Canada
5 Dept. of Nutrition, School of Public Health, Sun Yat-Sen University, 74 2nd Zhongshan Road, Guangzhou, Guangdong Province, 510080, PR China
BMC Cell Biology 2010, 11:56 doi:10.1186/1471-2121-11-56
Published: 16 July 2010Additional files
Additional file 1:
Forsklin/IBMX treatment causes Oct-1-EGFP shuttling from nuclear to cytoplasm. Treating the InR1G9 cell line with forskolin/IBMX led to increased Oct-1-EGFP content in the cytosol.
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Additional file 2:
cAMP promoting agents cause Oct-1-EGFP shuttling from nuclear to cytoplasm. Both membrane permeable cAMP analogue and the Epac pathway specific cAMP analogue increased Oct-1-EGFP content in the cytosol.
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