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Open Access Open Badges Research article

Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits

Dimitris Stellas1, Avraam El Hamidieh1 and Evangelia Patsavoudi12*

Author Affiliations

1 Department of Biochemistry, Hellenic Pasteur Institute, 127 Vasilissis Sofias Ave., 11521 Athens, Greece

2 Department of Medical Instrumentation, Technological Educational Institution of Athens, Ag. Spyridonos str., Egaleo, 12210 Athens, Greece

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BMC Cell Biology 2010, 11:51  doi:10.1186/1471-2121-11-51

Published: 5 July 2010

Additional files

Additional file 1:

Additional figure showing that the antibody against HSP90β does not recognize the HSP90α isoform. The western blot analysis of human recombinant HSP90α and total cell lysates (positive control) derived from MDAMB453 cell cultures using anti-HSP90α (positive control) and anti-HSP90β antibodies.

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Additional file 2:

Additional figure legend. A file containing the legend of the additional figure.

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