Figure 6.

Proposed Model by which Crosstalks Between ITGA5 and IGF2/IGFBP2 Signalling Trigger Osteogenic Differentiation in Human MSCs. ITGA5 expression induced by dexamethasone or ITGA5 activation by agonists upregulate signalling pathways that activate IGF2/IGFBP2 expression in hMSCs which in turn triggers osteoblast differentiation, revealing that ITGA5 and IGF2/IGFBP2 crosstalks are important mechanisms controlling osteogenic differentiation in human bone marrow derived mesenchymal stromal cells.

Hamidouche et al. BMC Cell Biology 2010 11:44   doi:10.1186/1471-2121-11-44
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