IGF2 and IGFBP2 Expression is Up-regulated During Osteoblast Differentiation of hMSCs. Adult hMSCs were treated with or without dexamethasone (10-7M) to induce osteoblastic differentiation. Total RNA was collected from three different donors and used for microarray hybridization. Data were normalized and genes that were upregulated (fold change >2) in dexamethasone-treated compared to untreated MSCs were subselected (A). Analysis of gene network using Ingenuity Software indicated interactions between IGF2, IGFBP2 and ITGA5 (B).
Hamidouche et al. BMC Cell Biology 2010 11:44 doi:10.1186/1471-2121-11-44