Model of the dynamic interaction of RCC1 with chromatin. RCC1 interacts weakly with a nucleosome through its core domain. Interaction of Ran-GDP releases GDP and leads to the transient formation of a binary complex between apoRan and RCC1 in which the methylated N-terminal tail undergoes a conformational change that allows it to interact with DNA and stabilise the association of RCC1. Binding of GTP to Ran causes dissociation of the binary complex and the release of RCC1 from the nucleosome.
Hitakomate et al. BMC Cell Biology 2010 11:43 doi:10.1186/1471-2121-11-43