Table 1 |
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|
Summary of chromosomal aberrations observed in cancer cells and normal cells with or without Ag-np treatment |
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|
IMR-90 |
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|
|
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|
Ag-NP μg/mL |
Metaphases analysed |
chromosome number |
Fragments |
breaks |
Fusions |
Total aberrations per cell |
Aberrant cells (%) |
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|
|
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|
(Mean ± s.e.) |
acentric |
centric |
(Mean ± s.e.) |
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|
|
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|
ring |
dicentric |
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|
|
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|
0 |
50 |
46 ± 0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
|||||||||
|
25 |
50 |
46 ± 0 |
4 |
1 |
0 |
0 |
0 |
0.094 ± 0.042 |
10% |
|
|
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|
U251 |
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|
|
|||||||||
|
Ag-NP μg/mL |
Metaphases analysed |
chromosome number |
fragments |
breaks |
fusions |
Total aberrations per cell |
Aberrant cells (%) |
||
|
|
|||||||||
|
(Mean ± s.e.) |
acentric |
centric |
(Mean ± s.e.) |
||||||
|
|
|||||||||
|
ring |
dicentric |
||||||||
|
|
|||||||||
|
0 |
50 |
93 ± 2.25 |
0 |
1 |
0 |
0 |
8 |
0.18 ± 0.062 |
16% |
|
|
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|
25 |
50 |
96 ± 2.46 |
6 |
3 |
0 |
0 |
7 |
0.32 ± 0.097 |
20% |
|
|
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|
Fifty metaphases were analysed per concentration. Higher concentrations of Ag-np did not yield sufficient number of metaphases for the analysis. Percentage of aberrant cells was expressed as number of cells which showed aberrations/number of metaphases analysed × 100. |
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|
AshaRani et al. BMC Cell Biology 2009 10:65 doi:10.1186/1471-2121-10-65 |
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