Table 1

Summary of chromosomal aberrations observed in cancer cells and normal cells with or without Ag-np treatment

IMR-90


Ag-NP

μg/mL

Metaphases analysed

chromosome number

Fragments

breaks

Fusions

Total aberrations

per cell

Aberrant cells (%)


(Mean ± s.e.)

acentric

centric

(Mean ± s.e.)


ring

dicentric


0

50

46 ± 0

0

0

0

0

0

0

0


25

50

46 ± 0

4

1

0

0

0

0.094 ± 0.042

10%


U251


Ag-NP

μg/mL

Metaphases analysed

chromosome number

fragments

breaks

fusions

Total aberrations

per cell

Aberrant cells (%)


(Mean ± s.e.)

acentric

centric

(Mean ± s.e.)


ring

dicentric


0

50

93 ± 2.25

0

1

0

0

8

0.18 ± 0.062

16%


25

50

96 ± 2.46

6

3

0

0

7

0.32 ± 0.097

20%


Fifty metaphases were analysed per concentration. Higher concentrations of Ag-np did not yield sufficient number of metaphases for the analysis. Percentage of aberrant cells was expressed as number of cells which showed aberrations/number of metaphases analysed × 100.

AshaRani et al. BMC Cell Biology 2009 10:65   doi:10.1186/1471-2121-10-65

Open Data