GX1 inhibits cell proliferation of both co-HUVEC and HUVEC through induction of apoptosis. GX1 was shown by MTT assay to suppress the proliferation of co-HUVEC (A) and HUVEC (B) in a dose-dependent manner. (C) GX1 had a greater inhibitory effect on co-HUVEC than HUVEC. (D) GX1 had no obvious effect on gastric adenocarcinoma SGC7901 cells. (E) GX1 at 50 μM significantly enhanced apoptosis of co-HUVEC over PBS treatment. The results are reported as mean ± SD of three independent experiments. Bars, SD. * p < 0.05, ** p < 0.01. (F) GX1 at 50 μM remarkably up-regulated caspase 3 expression level.
Chen et al. BMC Cell Biology 2009 10:63 doi:10.1186/1471-2121-10-63