Morphological analysis of 3D7 and Dd2 parasites using the Pathway HT. Parasite synchronized cultures were incubated for 72 hours with various concentrations of chloroquine, live-stained with the fluorometric RNA dye 132A and fixed-stained with Giemsa. Detailed images of infected erythrocytes show a decrease in fluorescence intensity, loss of nucleolus staining, and change of parasite morphology with increasing drug concentration.
Cervantes et al. BMC Cell Biology 2009 10:45 doi:10.1186/1471-2121-10-45