β-catenin stabilization has a minor effect on collagen lattice contraction compared to transforming growth factor β. A. Means and 95% confidence intervals for collagen lattice areas as observed over seven days for fibroblasts from mice expressing stabilized β-catenin alleles or wild type littermates treated with the adenovirus expressing cre recombinase, also treated with either transforming growth factor β, or carrier. There is a statistically significant difference between transforming growth factor β and carrier treatment for all time points after day three, and a statistically significant difference between fibroblasts in which the stabilized β-catenin allele was activated compared to fibroblasts from wild type mice for the time points with an asterisk above the data points. Data obtained using serum free media is shown. B. Representative photographs of the collagen lattices at day seven.
Poon et al. BMC Cell Biology 2009 10:38 doi:10.1186/1471-2121-10-38