Transforming growth factor β induces collagen lattice contraction independent of β-catenin. A Means and 95% confidence intervals for collagen lattice mean diameter as observed over seven days for fibroblasts from mice expressing null β-catenin alleles or wild type littermates treated with the adenovirus expressing cre recombinase also treated with transforming growth factor β, or the carrier. There is a statistically significant difference between transforming growth factor β and carrier treatment for time points identified with an asterisk above the point, but no statistically significant difference between fibroblasts in which the β-catenin null allele was activated compared to treatment with transforming growth factor. Data is shown in the absence of serum. B. Representative photographs of the collagen lattices at day seven.
Poon et al. BMC Cell Biology 2009 10:38 doi:10.1186/1471-2121-10-38