Table 1

A summary of the anti-angiogenic properties of stilbene glycosides.

Assay

Compound 1

Compound 2

BAEC

HDMEC

BAEC

HDMEC


Proliferation in 15% FBS

NS

NS

NS

NS

EGF-induced proliferation

NS

NS

NS

NS

VEGF-induced proliferation

NS

NS

NS

NS

FGF-2-induced proliferation

48.90 ± 0.40

42.0 ± 0.93

NS

101.0 ± 0.50

FGF-2-induced migration

41.8 ± 0.95

ND

NS

ND

FGF-2-induced chemotaxis

30.05 ± 0.85

21.50 ± 0.6

800.0 ± 2.78

953.1 ± 3.50

FGF-2-induced tube formation

18.20 ± 0.65

12.4 ± 0.85

NS

NS

FGF-2 invasion in matrigel

11.12 ± 0.28

5.8 ± 0.18

18.90 ± 0.50

32.46 ± 0.95

Tubular regression

40.0 ± 0.2

ND

37.42 ± 0.63

ND

Effect on binding to FGFR-1

5.37 ± 1.04

NS

Effect on binding to FGFR-2

9.32 ± 0.082

NS

In vivo CAM assay

100% inhibition

90% inhibition


NS = Not significant, overall inhibition is less than 50% and therefore IC50 values cannot be calculated. ND = not determined

Figures are the IC50 values ± SD (μM) and are the mean of at least three determinations.

Hussain et al. BMC Cell Biology 2009 10:30   doi:10.1186/1471-2121-10-30

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