Figure 13.

Putative mechanism of apoptosis of SH-SY5Y cells induced by rib-glycated BSA. Glycation of BSA with rib induces protein misfolding and results in the formation of amyloid-like aggregations with high cytotoxicity that trigger cell death by the activation of cellular signalling cascades.

Wei et al. BMC Cell Biology 2009 10:10   doi:10.1186/1471-2121-10-10
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