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Open Access Highly Accessed Research article

Rapid glycation with D-ribose induces globular amyloid-like aggregations of BSA with high cytotoxicity to SH-SY5Y cells

Yan Wei12, Lan Chen1, Ji Chen2, Lin Ge2 and Rong Qiao He12*

Author Affiliations

1 State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 15 Da Tun Road, Chaoyang District, Beijing, 100101, PR China

2 Graduate University of Chinese Academy of Sciences, 19A Yu Quan Road, Shijingshan District, Beijing, 100039, PR China

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BMC Cell Biology 2009, 10:10  doi:10.1186/1471-2121-10-10

Published: 13 February 2009

Additional files

Additional file 1:

Changes in CD spectra of BSA in the presence of D-ribose. Incubation conditions were as in Figure 1, except that aliquots of the incubation mixtures were taken for measurement of the CD spectra at different time intervals. BSA (A), BSA with rib (B).

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Additional file 2:

Observation of BSA by atomic force microscopy. Incubation conditions were as in Figure 6A, except that BSA alone was observed rather than BSA incubated with rib.

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