Figure 1.

Example CCS detected between H. sapiens and S. cerevisiae. The figure shows a conserved and connected subgraph between H. sapiens (circle) and S. cerevisiae (hexagon). Proteins of both species are involved in mRNA splicing and are known to exhibit splicing factor activity to bind the mRNA and support the splicing process. (Solid lines represent conserved PPIs within a species and dashed lines indicate orthology relationships between proteins.)