Table 1 |
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|
Pathways involved in the HIV-VLPs-induced PBMCs. The pathways are derived from the BioCarta through the Cancer Genome Anatomy Project at http://cgap.nci.nih.gov/Pathways/BioCarta_Pathways webcite. Genes with at least a 1.5-fold modulation (up or downregulation) have been taken into consideration. |
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|
Pathways |
VLP vs PBS Up-regulated |
Pathways |
VLP vs PBS Down-regulated |
|
|
Antigen processing and presentation |
CTSL |
ECM-receptor interaction |
CD36 |
|
|
Cell cycle, proliferation, cell death |
IL3RA
|
Cytokine-cytokine receptor interaction |
IL1R2 |
|
|
Cell shape & extracellular matrix |
SERPINB2
|
Chaperones modulate interferon Signaling Pathway |
HSPA7 |
|
|
Chemokine and cytokines |
IL6
|
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|
Cytokine Network |
IL1-A
|
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|
Cytokine-cytokine receptor interaction |
CCL18
|
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|
Immune response |
ACTN1 |
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|
Membrane proteins |
AQP9
|
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|
Transcription |
MAD |
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|
Selective expression of chemokine receptors during T-cell polarization/Toll-like receptor signaling pathway |
CCL4 (MIP1β)
|
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|
|
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|
Buonaguro et al. BMC Bioinformatics 2008 9(Suppl 2):S5 doi:10.1186/1471-2105-9-S2-S5 |
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