Receiver Operating Characteristic (ROC) curves for various tree cutting strategies, using the Ward's method clustering based on the VAST Nres similarity score. The true positive rate (TPR, Y axis) is plotted against the false positive rate (FPR, X axis). Black curves correspond to largest size cut (solid line), longest branch cut (dotted line) and level cut (dash-dot line) strategies, which use only of tree topology parameters. The red dotted curve corresponds to the MI cut strategy, which uses SCOP classification information directly, so is viewed only as an approximate upper bound to the SCOP-independent strategies. The Y-axis intercept for this curve is 0.45 and close to 0.0 for all SCOP-independent strategies. Only the portion of the curve for FPR values below 0.45 is shown. Between this FPR value and 0.63 relative positions of the curves do not vary. Above 0.63 FPR value all curve superpose to the MI cut curve.
Sam et al. BMC Bioinformatics 2008 9:74 doi:10.1186/1471-2105-9-74