BMC Bioinformatics

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AnEnPi: identification and annotation of analogous enzymes

Thomas D Otto*, Ana CR Guimarães, Wim M Degrave and Antonio B de Miranda

BMC Bioinformatics 2008, 9:544 doi:10.1186/1471-2105-9-544

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Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution

Marina V Omelchenko, Michael Y Galperin, Yuri I Wolf, Eugene V Koonin Biology Direct 2010, 5:31 (30 April 2010)

Almost 10% of the biochemical reactions in the Enzyme Commission nomenclature are catalyzed by two or more enzymes with different structural folds and hence independent evolutionary origins.