Figure 3.

Pathway coherence in normal prostate samples. (a) Q-Q plot of mean correlation across all genes for each pathway vs. coherenece for each pathway. Pathway coherence has a much broader distribution; in particular, pathway coherence exceeding 0.7 is much more common than the average gene-pathway correlation (across all genes not on the pathway). (b) Pathway coherence vs. pathway length for normal prostate (black circles) and prostate tumor (red crosses) samples; pathway coherence is systematically lower in tumor samples.