BMC Bioinformatics

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Open Access Highly Access Methodology article

Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios

Johan Staaf1,2, Johan Vallon-Christersson1,2, David Lindgren1, Gunnar Juliusson3, Richard Rosenquist4, Mattias Höglund1, Åke Borg1,2,3 and Markus Ringnér1,2*

Author Affiliations

1 Department of Oncology, Clinical Sciences, Lund University, SE-22185 Lund, Sweden

2 CREATE Health Strategic Centre for Clinical Cancer Research, Lund University, SE-22184 Lund, Sweden

3 Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, SE-22184 Lund, Sweden

4 Department of Genetics and Pathology, Uppsala University, SE-75185 Uppsala, Sweden

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BMC Bioinformatics 2008, 9:409 doi:10.1186/1471-2105-9-409

Published: 2 October 2008

Additional files

Additional file 1:

Supplementary figures. This file contains supplementary figures on the effect of BAF asymmetry on downstream analysis, a comparison of CN estimates before and after tQN, and a comparison of BAF asymmetry for regions of allelic imbalance before and after tQN.

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