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Open AccessHighly AccessMethodology article

Integration of relational and hierarchical network information for protein function prediction

Xiaoyu Jiang1 email, Naoki Nariai2 email, Martin Steffen3,4 email, Simon Kasif2,4 email and Eric D Kolaczyk1 email

1Department of Mathematics and Statistics, Boston University, Boston, MA 02215, USA

2Bioinformatics Program, Boston University, Boston MA, 02215, USA

3Department of Genetics and Genomics, Boston University, Boston MA, 02118, USA

4Department of Biomedical Engineering, Boston University, Boston MA, 02215, USA

author email corresponding author email

BMC Bioinformatics 2008, 9:350doi:10.1186/1471-2105-9-350

Published: 22 August 2008

Additional files

Additional file 1:

ROC curves and hF plots for 47 sub-hierarchies in cross-validation study. This file contains the ROC curves and plots of hF score versus predicting threshold of the three methods for 47 individual sub-hierarchies in the 5-fold cross-validation study. The root term ID's and names of the root terms, the sizes of sub-hierarchies, numbers of terms and genes predicted within sub-hierarchy are also shown. Colors: HBN (red); BN (light blue); NN (blue).

Format: PDF Size: 3.3MB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional file 2:

hF plots for 17 sub-hierarchies in in silico study. This file contains the plots of hF score versus threshold of the three methods for individual sub-hierarchies in the in silico validation study. The root term ID's and names of the root terms, the sizes of sub-hierarchies, numbers of terms and genes predicted within sub-hierarchy are also shown. Colors: HBN (red); BN (light blue); NN (blue).

Format: PDF Size: 411KB Download file

This file can be viewed with: Adobe Acrobat Reader


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