Table 1 |
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|
Block Design Example |
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|
Number of blocks (B) |
Number of compounds per block (nB) |
Number of active compounds expected per block (dB) |
Number of tests needed per block (tB) |
Actual error-rate handled (e) |
Actual mixing constraint (m) |
Total number of tests needed (t) |
|
|
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|
1 |
10000 |
3 |
- |
- |
- |
- |
|
25 |
400 |
1 |
492 |
1.02% |
10 |
12300 |
|
50 |
200 |
1 |
92 |
1.09% |
9 |
4600 |
|
77 |
130 |
1 |
52 |
1.92% |
10 |
4004 |
|
91 |
110 |
1 |
44 |
2.27% |
10 |
4004 |
|
100 |
100 |
1 |
44 |
2.27% |
10 |
4400 |
|
500 |
20 |
1 |
20 |
5% |
4 |
10000 |
|
|
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|
Sample case of n = 10, 000, d = 3, e = 1% and m = 10 showing the efficiency of selected block design parameters. The choice of error-rate (e = 1%) does not permit a full library design (first row), thus it is left empty. |
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|
Kainkaryam and Woolf BMC Bioinformatics 2008 9:256 doi:10.1186/1471-2105-9-256 |
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