BMC Bioinformatics

official impact factor 3.03

Open Access Highly Access Methodology article

Gene prediction in metagenomic fragments: A large scale machine learning approach

Katharina J Hoff1*, Maike Tech1, Thomas Lingner1, Rolf Daniel2, Burkhard Morgenstern1 and Peter Meinicke1

Author Affiliations

1 Abteilung Bioinformatik, Georg-August-Universität Göttingen, Goldschmidtstr. 1, 37077 Göttingen, Germany

2 Abteilung Genomische und Angewandte Mikrobiologie, Georg-August-Universität Göttingen, Goldschmidtstr. 1, 37077 Göttingen, Germany

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BMC Bioinformatics 2008, 9:217 doi:10.1186/1471-2105-9-217

Published: 28 April 2008

Additional files

Additional file 1:

Tables with training genomes, discriminant weights, and network parameters. The tables list all genomes that were used for training the neural network (1), present the discriminant weights that were learned for all monocodons (2), and give neural network parameters (3, 4).

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Additional file 2:

Supplementary figures. The figures show the area under precision recall curve for discriminant validation using different λ values (1), the neural network performance with increasing numbers of nodes (2), the percentage of complete genes within all annotated genes per fragment for different fragment lengths (3), and gene prediction performance on fragments ranging from 5000 to 60000 bp (4).

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