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Open AccessHighly AccessResearch article

Improving protein function prediction methods with integrated literature data

Aaron P Gabow1 email, Sonia M Leach1,3 email, William A Baumgartner1 email, Lawrence E Hunter1,2 email and Debra S Goldberg1,2 email

1Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, MS 8303, RC-1 South, 12801 East 17th Avenue, L18-6101, PO Box 6511, Aurora, CO 80045, USA

2Department of Computer Science, University of Colorado at Boulder, Boulder, CO 80309, USA

3Department of Electrical Engineering (ESAT), Research Division SCD, Katholieke Universiteit Leuven, B-3001 Leuven, Belgium

author email corresponding author email

BMC Bioinformatics 2008, 9:198doi:10.1186/1471-2105-9-198

Published: 15 April 2008

Additional files

Additional file 1:

Yeast co-occurrence graph where ACF is greater than .9. The complete PPI and co-occurrence network using ACF scoring at the highest threshold. Nodes correspond to yeast proteins and are colored by GO SLIM categories such that white nodes indicate Unknown Function. Edges between nodes x and y indicate ACF(x, y) > 0.9. Note that at this threshold, large clusters of like color indicate protein families.

Format: PDF Size: 160KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional file 2:

Worm co-occurrence graph where ACF is greater than .9. The complete PPI and co-occurrence network using ACF scoring at the highest threshold. Nodes correspond to yeast proteins and are colored by GO SLIM categories such that white nodes indicate Unknown Function. Edges between nodes x and y indicate ACF(x, y) > 0.9. Note that at this threshold, large clusters of like color indicate protein families.

Format: PDF Size: 66KB Download file

This file can be viewed with: Adobe Acrobat Reader

Additional file 3:

Fly co-occurrence graph where ACF is greater than .9. The complete PPI and co-occurrence network using ACF scoring at the highest threshold. Nodes correspond to yeast proteins and are colored by GO SLIM categories such that white nodes indicate Unknown Function. Edges between nodes x and y indicate ACF(x, y) > 0.9. Note that at this threshold, large clusters of like color indicate protein families.

Format: PDF Size: 60KB Download file

This file can be viewed with: Adobe Acrobat Reader


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