Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions

Leah E Mechanic¹ , Brian T Luke² , Julie E Goodman³ , Stephen J Chanock⁴ and Curtis C Harris¹

¹  Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA

²  SAIC-Frederick, Advanced Biomedical Computing Center, National Cancer Institute, NIH, Frederick, MD, USA

³  Gradient, Inc.; Boston, MA, USA

⁴  Pediatric Oncology Branch, National Cancer Institute, Advanced Technology Center, Gaithersburg, MD, USA