Figure 10.

The TKF92 model [9], presented as a Hidden Markov Model. λ is the insertion rate, μ is the deletion rate, r is the parameter of the geometric distribution of inserted and deleted fragments, <a onClick="popup('http://www.biomedcentral.com/1471-2105/9/137/mathml/M1','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2105/9/137/mathml/M1">View MathML</a>. Emission probabilities are given by the time-continuous substitution model of the TKF92 model, the probability of joint emission of two characters equals the joint observation probability of two characters under the substitution model, single emissions follow the equilibrium distribution of the substitution process.

Miklós et al. BMC Bioinformatics 2008 9:137   doi:10.1186/1471-2105-9-137
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