Figure 1.

Choosing size of the signature. The relationship between the number of features in a prognostic signature and the specificity at 90% sensitivity of the corresponding prognostic test, evaluated by 40-fold cross-validation. We select mopt = 80, the smallest value that achieves roughly maximum specificity at the 90% sensitivity level. The specificity observed on the validation set is in fact higher.

Xu et al. BMC Bioinformatics 2008 9:125   doi:10.1186/1471-2105-9-125
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