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Open AccessHighly AccessResearch article

Strategies for measuring evolutionary conservation of RNA secondary structures

Andreas R Gruber1 email, Stephan H Bernhart1,2 email, Ivo L Hofacker1 email and Stefan Washietl1,3 email

1Institute for Theoretical Chemistry, University of Vienna, Währingerstraße 17, 1090 Wien, Austria

2Bioinformatics Group, Department of Computer Science, University of Leipzig, Härtelstrasse 16-18, D-04109 Leipzig, Germany

3EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

author email corresponding author email

BMC Bioinformatics 2008, 9:122doi:10.1186/1471-2105-9-122

Published: 26 February 2008

Additional files

Additional file 1:

Overview of the BRAliBase 2.1 dataset. Overview of the BRAliBase 2.1 data set. The number of the alignments in the different entropy bins are shown. The red line indicates the minimal threshold of positive instances we used to obtain reasonable significance levels in the ROC analysis. Bins below this threshold were not considered.

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