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Gusev Y
Schmittgen TD
Lerner M
Postier R
Brackett D

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Schmittgen TD
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Postier R
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This article is part of the supplement: Proceedings of the Fourth Annual MCBIOS Conference. Computational Frontiers in Biomedicine

Proceedings

Computational analysis of biological functions and pathways collectively targeted by co-expressed microRNAs in cancer

Yuriy Gusev¹ , Thomas D Schmittgen² , Megan Lerner¹^,3 , Russell Postier¹ and Daniel Brackett¹^,3

¹Department of Surgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

²Division of Pharmaceutics, Ohio State University, Columbus, Ohio, USA

³Veterans Affairs Medical Hospital, Oklahoma City, Oklahoma, USA

author email corresponding author email

BMC Bioinformatics 2007, 8(Suppl 7):S16doi:10.1186/1471-2105-8-S7-S16


Published:	1 November 2007

Additional files

Additional file 1:

Supplemental Figure 2 – Top ranked biological functions and disease categories targeted by miRNAs and known to be affected in Colon Cancer. A. Top 5 Biological Functions. B. Top 5 Disease Categories

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Additional file 2:

Supplemental Figure 3 – Top ranked biological functions and disease categories targeted by miRNAs and known to be affected in Pancreatic Cancer. A. Top 5 Biological Functions. B. Top 5 Disease Categories

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Additional file 3:

Top 5 functions, disease categories and toxicology lists for 5 cancers.

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Additional file 4:

Supplemental Figure 1 – Comparison of Toxicology categories and canonical pathways targeted by miRNA for 5 types of cancer. A. Toxicology related gene lists from top ranked Toxicology categories. B. Top ranked Canonical Pathways

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Additional file 5:

Supplemental Figure 5 – Comparison of top ranked signaling pathways targeted by microRNAs in 5 types of cancer. A. Ratio of the number of genes targeted by miRNAs to the total number of genes in each pathway. B. Significance of overrepresentation of microRNA targets in each pathway

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Additional file 6:

Supplemental Figure 4 – TGF-b Signaling pathway. A. Genes known to be affected in Lymphoma (shown in gray) and known anticancer drugs. B. Targets of microRNA family miR-17-92 (shown in gray) and targets of known anticancer drugs. Drug that are known to target genes from this signaling pathway are outlined in dark blue. Drug targets are outlined in light blue.

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Additional file 7:

Supplemental Table 1 – Number of predicted miRNA target genes known to be associated with specific or any cancer and targeted by anti-cancer drugs.

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Additional file 8:

Supplemental Tables: genes known to be affected in specific cancer and targeted by miRNAs (lymphoma, breast cancer, lung cancer).

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