Additional file 1.

The .pdf document contains a detailed description of the procedure used to standardize the variable dH0 so as to account for the error intensity dependent distribution, and a detailed description of the procedure used to simulate the data, based on a first order Markov Model.

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Di Camillo et al. BMC Bioinformatics 2007 8(Suppl 1):S10   doi:10.1186/1471-2105-8-S1-S10