Table 5

Comparison of the different AGGRESCAN parameters for globular, natively unstructured, amyloidogenic, soluble and insoluble proteins.

Set Name

Globular1

Unfolded2

Amyloid3

IBs4

Soluble5


a3vSA

-0.04

-0.28

-0.12

-0.02

-0.05

nHS

9.54

5.63

5.86

11.97

10.34

NnHS

3.89

2.06

2.89

3.50

3.35

AAT

29.94

18.21

24.51

41.27

34.43

THSA

25.58

14.97

21.26

36.00

29.61

TA

-5.17

-60.95

-26.42

-5.00

-5.55

AATr

0.12

0.07

0.13

0.13

0.12

THSAr

0.11

0.05

0.11

0.11

0.09

Na4vSS

-4.26

-28.73

-12.96

-2.51

-5.18


In bold and italics are shown those parameters that are normalized by the number of residues, allowing direct comparison of datasets independently of protein size.

1Natively globular proteins: 160 proteins randomly selected from SCOP (the ASTRAL40 set)

2Natively intrinsically unstructured proteins: 51 proteins

3Amyloidogenic proteins: 57 proteins

4Proteins forming inclusion bodies when overexpressed in bacteria: 121 proteins

5Proteins which are soluble when overexpressed in bacteria: 38 proteins

Conchillo-SolĂ© et al. BMC Bioinformatics 2007 8:65   doi:10.1186/1471-2105-8-65

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