Table 1

List and ranking of the predicted aggregation-prone regions in the different disease-linked polypeptides analyzed in this study and comparison with the available experimental data.

Protein

Experimental regiona

Predicted regionb

Rankingc

References


Abri

1–34

4–9

2/2

[52]

15–28

1/2

Adan

1–34

4–9

2/2

[53]

15–24

1/2

68–78

66–77

1/6

[54–56]

α-Synuclein

31–109

36–42

2/6

[56]

49–55

4/6

87–94

5/6

Amphoterin

12–27

14–22

2/3

[57]

Amyloid-β-protein

17–21

17–22

2/2

[58]

31–36/38–42

30–42

1/2

Apoliprotein A-I

1–83

13–21

2/2

[59]

Apoliprotein A-II

N-terminal fragments

1–19

1/3

[11]

Apoliprotein A-IV

N-terminal fragments

1–19

1/6

[11]

Apoliprotein C-II

57–74

60–67

2/3

[60]

69–76

1/3

β2-Microgobulin

21–41

22–30

2/2

[61]

59–79

59–70

1/2

[62]

Exon 30 Tropoelastin

1–25

1–7

2/2

[63]

9/18

1/2

Fibrinogen A α-chain

501–506

499–521

1/6

[64]

482–504

501–506

1/5

Glycophorin A

70–98

74–98

1/4

[65]

Insulin

1–38

12–19

1/3

[66]

21–27

3/3

Islet amyloid polypeptide

8–20

13–18

1/2

[67]

20–29

24–28

2/2

[68]

Lysozyme (Hen)

40–64

54–62

2/4

[69]

49–101

76–84

3/4

[70]

Medin

47–54

49–55

1/3

[71]

Myoglobin (Horse)

101–118

101–115

1/4

[72]

Prion Protein

106–147

117–136

3/6

[73]

138–142

6/6

Prolactin

1–34

10–32

2/9

[74]

Pulmonary surfactant protein

24–58

31–59

1/5

[25]

Serum Amyloid A

2–12

1–9

1/2

[75]

Tau

301–320

304–311

1/2

[27]

10–20

12–19

2/7

[76]

Transthyretin

105–115

105–112

3/7

[77]

114–123

4/7


aSequence stretches experimentally identified as critical for protein aggregation.

bCoincident aggregation-prone segments as predicted by AGGRESCAN.

cThe rank position refers to the entire protein and reflects the importance of this specific "hot spot" (HS) relative to all the aggregation-prone regions identified by AGGRESCAN in the protein. (i.e., 1/4 indicates that this HS has the highest aggregation propensity of the four detected in a particular sequence by the software)

Conchillo-Solé et al. BMC Bioinformatics 2007 8:65   doi:10.1186/1471-2105-8-65

Open Data