Model structures for Tabasco and species-level simulations of expression of a single gene. We simulated expression of a single gene using a standard species-level SSA, and using the Tabasco gene expression simulator (Figure 3). The Tabasco-based simulation uses a transcription initiation model (a) with the rest of gene expression using the general schematic shown in Figure 1. We constructed the model for the species-level simulator (b) to mimic the Tabasco-based model, except that elongation reactions were treated as single-lumped reactions.
Kosuri et al. BMC Bioinformatics 2007 8:480 doi:10.1186/1471-2105-8-480