Differences in single-step and multi-step elongation processes. Simulating the elongation of RNA polymerase along 50 based of DNA as a one-step elongation process versus a chain of individual elongation events gives the same average elongation time, but produces marked differences in the distribution of those elongation times. The process shown here is either a single 1.0 second elongation step (red) or fifty 0.02 second elongation steps (blue). Each histogram is the distribution of resulting times from 20,000 independent simulations.
Kosuri et al. BMC Bioinformatics 2007 8:480 doi:10.1186/1471-2105-8-480