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Open AccessResearch article

Predicting combinatorial binding of transcription factors to regulatory elements in the human genome by association rule mining

Xochitl C Morgan1* email, Shulin Ni2 email, Daniel P Miranker2 email and Vishwanath R Iyer1 email

Institute for Cellular and Molecular Biology and Center for Systems and Synthetic Biology, The University of Texas at Austin, Austin, Texas 78712-0159, USA

Department of Computer Science, The University of Texas at Austin, Austin, Texas 78712-0159, USA

author email corresponding author email* Contributed equally

BMC Bioinformatics 2007, 8:445doi:10.1186/1471-2105-8-445

Published: 15 November 2007

Additional files

Additional file 1:

83 transcription factors from TRANSFAC. A list of the 83 transcription factor position weight matrices from TRANSFAC used for this analysis.

Format: DOC Size: 30KB Download file

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Additional file 2:

Effects of repeat masking. Support, confidence A=>B, and confidence B=>A are highly correlated between hg17 without repeat masking and hg18 with repeat masking.

Format: TIFF Size: 1.2MB Download file

Additional file 3:

The subsets "genomewide", "mouse", and "promoter". "Genomewide", "Promoter", and "Mouse" are defined as top 50% difference between confidence A=>B and confidence B=>A and P < 0.05 as measured by the hypergeometric distribution. Pairs indicated in bold have been verified in the literature.

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Additional file 4:

Estimated Patser error rates for PWMs. Approximate overestimation rates of position weight matrices from Patser.

Format: DOC Size: 78KB Download file

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