BMC Bioinformatics

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Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool 'CubeX'

Tom R Gaunt*, Santiago Rodríguez and Ian NM Day

Author Affiliations

Bristol Genetic Epidemology Laboratories (BGEL) and MRC Centre for Causal Analyses in Translational Epidemiology (CAiTE), Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK

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BMC Bioinformatics 2007, 8:428 doi:10.1186/1471-2105-8-428

Published: 2 November 2007

Additional files

Additional file 1:

Comparisons of PHASE, MIDAS and CubeX on APOE data (from [25]). A comparison of PHASE, MIDAS and CubeX for pairwise analysis of genotype data derived from directly observed multi-locus haplotypes.

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Additional file 2:

Comparisons of PHASE, MIDAS and CubeX on HapMap IGF2 region data (from http://www.hapmap.org webcite, [23,24]). A comparison of PHASE, MIDAS and CubeX for pairwise analysis of genotype data derived from statistically inferred long-range multi-locus haplotypes.

Format: PDF Size: 81KB Download file

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Open Data