Resolution:
## Figure 1.
Overview of methods. (A) The main method of identifying subsystems only requires a set of attractors
(*). These attractors can be found either from a model or directly from experimental
data, meaning that a known network topology is not essential. (B) More detailed schematic
of the methods, showing the procedures required at each step (given in the Methods section). The attractors are used to find intersection sequences and partition sequences
(Stage 1), which are then used to identify subsystems (stage 2). Once the subsystems
are identified, regulation sets can be found with the help of a suitable mathematical
model.
Irons and Monk |