Correlation between (a) experimental ln(kcat /Km and (b) experimental ln(Km for the substrate ATCh and electrostatic potential differences for different AChE mutants. Each point corresponds to the differences for one protein variant pair. The straight line corresponds to the best linear fit and is given by y = -1.06*x (a) and y = 1.68*x (b). In the panel (a) data for protein pairs that do not have active site residue mutations are shown by filled circles.
Gabdoulline et al. BMC Bioinformatics 2007 8:373 doi:10.1186/1471-2105-8-373