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Open Access Highly Accessed Research article

Reduced modeling of signal transduction – a modular approach

Markus Koschorreck*, Holger Conzelmann, Sybille Ebert, Michael Ederer and Ernst Dieter Gilles

Author Affiliations

Max Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106 Magdeburg, Germany

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BMC Bioinformatics 2007, 8:336  doi:10.1186/1471-2105-8-336

Published: 13 September 2007

Additional files

Additional file 1:

Transformation and stationary error

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Additional file 2:

Transformation and stationary error

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Additional file 3:

Layer based reduced modeling of insulin signaling

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Additional file 4:

Documentation and analysis of the larger example system

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Additional file 5:

Layer based reduced model of the larger example system

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Additional file 6:

Layer based reduced model of insulin signaling (214 ODEs)

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Additional file 7:

Application of the domain oriented approach to the insulin model with 214 ODEs

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Additional file 8:

Reduced model resulting from combination of both approaches (56 ODEs)

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